Purified prion proteins and scrapie infectivity copartition into liposomes.

Considerable evidence indicates that the scrapie prion protein (PrP 27-30) is required for infectivity. Aggregates of PrP 27-30 form insoluble amyloid rods that resist dissociation by nondenaturing detergents. Mixtures of the detergent cholate and phospholipids were found to solubilize purified PrP...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Gabizon, R, McKinley, M P, Prusiner, S B
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1987
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305012/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3108886/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.12.4017
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