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New Site(s) of Methylglyoxal-Modified Human Serum Albumin, Identified by Multiple Reaction Monitoring, Alter Warfarin Binding and Prostaglandin Metabolism
Methylglyoxal (MG) is a biologically reactive byproduct of glucose metabolism levels of which increase in diabetes. MG modification of protein generates neutral hydroimidazolone adducts on arginine residues which can alter functional active sites. We investigated the site-specificity of MG adduction...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050118/ https://ncbi.nlm.nih.gov/pubmed/20934417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2010.09.032 |
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