Naturally-Occurring Mutation in the Calcium-Sensing Receptor Reveals the Significance of Extracellular Domain Loop III Region for Class C G-Protein-Coupled Receptor Function

Context: Inactivating mutations of the calcium-sensing receptor (CaSR) cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Most mutations are clustered in the N-terminal and Cys-rich regions of the extracellular domain (ECD) and seven-transmembrane domain. Disease-cau...

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Detalhes bibliográficos
Main Authors: Dong, Qing, Cheng, Zhiqiang, Chang, Wenhan, Blackman, Brigitte E., Conte, Felix A., Hu, Jianxin, Shoback, Dolores, Miller, Walter L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050095/
https://ncbi.nlm.nih.gov/pubmed/20631026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-0559
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