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Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70(S6K) activities in the liver of obese Zucker rats
Calorie restriction (CR) improves obesity-related insulin resistance through undefined molecular mechanisms. Insulin receptor substrate (IRS)-1 serine/threonine kinases have been proposed to modulate insulin sensitivity through phosphorylation of IRS proteins. The aim of this study is to test the hy...
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Principais autores: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050029/ https://ncbi.nlm.nih.gov/pubmed/19801385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-09-0181 |
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