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How does cAMP/Protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
The overwhelming majority of benign lesions of the adrenal cortex leading to Cushing syndrome are linked to one or another abnormality of the cAMP signaling pathway. A small number of both massive macronodular adrenocortical disease and cortisol-producing adenomas harbor somatic GNAS mutations. Micr...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049838/ https://ncbi.nlm.nih.gov/pubmed/21111774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2010.11.018 |
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