Liver X Receptor Signaling is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease

BACKGROUND & AIMS: Liver X receptors (LXRs) are lipid-activated nuclear receptors with important roles in cholesterol transport, lipogenesis, and anti-inflammatory signaling. Hepatic stellate cells (HSCs) activate during chronic liver injury and mediate the fibrotic response. These cells are als...

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Hauptverfasser: Beaven, Simon W., Wroblewski, Kevin, Wang, Jiaohong, Hong, Cynthia, Bensinger, Steven, Tsukamoto, Hide, Tontonoz, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049833/
https://ncbi.nlm.nih.gov/pubmed/21134374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.11.053
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