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Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging
BACKGROUND: Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to be a principal mechanism of aging. Here we tested this hypothesis in healthy individuals of different ages by examining unrepaired DNA double-strand breaks (DSBs) in hematopoietic stem/progenitor cells...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049780/ https://ncbi.nlm.nih.gov/pubmed/21408175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017487 |
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