Simultaneous monitoring of tissue P(2) and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices

Nicotinamide adenine dinucleotide (NADH) imaging can be used to monitor neuronal activation and ascertain mitochondrial dysfunction, for example during hypoxia. During neuronal stimulation in vitro, NADH normally becomes more oxidized, indicating enhanced oxygen utilization. A subsequent NADH oversh...

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Detalhes bibliográficos
Main Authors: Galeffi, Francesca, Somjen, George G, Foster, Kelley A, Turner, Dennis A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049517/
https://ncbi.nlm.nih.gov/pubmed/20736960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.136
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