Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [(11)C] NNC112 and [(11)C] raclopride

DAR-0100A, the active enantiomer of dihydrexidine, is a potent dopamine D1 agonist under investigation for treatment of cognitive impairment and negative symptoms of schizophrenia. We measured the dose–occupancy relationship for DAR-0100A at D1 receptors using positron emission tomography (PET) imag...

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Bibliografske podrobnosti
Main Authors: Slifstein, Mark, Suckow, Raymond F, Javitch, Jonathan A, Cooper, Thomas, Lieberman, Jeffrey, Abi-Dargham, Anissa
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049493/
https://ncbi.nlm.nih.gov/pubmed/20571519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.91
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