Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model

Cerebral ischemia that develops after subarachnoid hemorrhage (SAH) carries high morbidity and mortality. Inflammatory mediators are involved in the development of cerebral ischemia through activation of the mitogen-activated protein kinase pathway. We hypothesized that blockade of the MAPkinase/ERK...

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Main Authors: Maddahi, Aida, Ansar, Saema, Chen, Qingwen, Edvinsson, Lars
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049479/
https://ncbi.nlm.nih.gov/pubmed/20424636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.62
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