Microdialysis with radiometric monitoring of -[β-(11)C]DOPA to assess dopaminergic metabolism: effect of inhibitors of -amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysate

The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy--phenylalanine (-DOPA) by aromatic -amino acid decarboxylase (AADC). Dopamine metabolism is regulated by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT). To measure dopaminergic metabolism, we used microdialysis with...

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Detalhes bibliográficos
Main Authors: Okada, Maki, Nakao, Ryuji, Hosoi, Rie, Zhang, Ming-Rong, Fukumura, Toshimitsu, Suzuki, Kazutoshi, Inoue, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049477/
https://ncbi.nlm.nih.gov/pubmed/20407462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.58
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