Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation

The transcription factor p53 is a tumor suppressor. As such, the P53 gene is frequently altered in human cancers. However, over 80% of the P53 mutations found in human cancers are missense mutations that lead to expression of mutant proteins that not only lack p53 transcriptional activity but exhibi...

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Bibliografiske detaljer
Main Authors: Wang, Yongxing, Suh, Young-Ah, Fuller, Maren Y., Jackson, James G., Xiong, Shunbin, Terzian, Tamara, Quintás-Cardama, Alfonso, Bankson, James A., El-Naggar, Adel K., Lozano, Guillermina
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049366/
https://ncbi.nlm.nih.gov/pubmed/21285512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44504
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