Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency

Fifteen variants in 10q26 are in strong linkage disequilibrium and are associated with an increased risk for age-related macular degeneration (AMD), a frequent cause of blindness in developed countries. These variants tag a single-risk haplotype encompassing the genes ARMS2 (age-related maculopathy...

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Main Authors: Friedrich, Ulrike, Myers, Connie A., Fritsche, Lars G., Milenkovich, Andrea, Wolf, Armin, Corbo, Joseph C., Weber, Bernhard H.F.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049360/
https://ncbi.nlm.nih.gov/pubmed/21252205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr020
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