Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice

Duchenne muscular dystrophy, the most common form of childhood muscular dystrophy, is caused by X-linked inherited mutations in the dystrophin gene. Dystrophin deficiencies result in the loss of the dystrophin–glycoprotein complex at the plasma membrane, which leads to structural instability and mus...

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Hlavní autoři: Kim, Michelle H., Kay, Danielle I., Rudra, Renuka T., Chen, Bo Ming, Hsu, Nigel, Izumiya, Yasuhiro, Martinez, Leonel, Spencer, Melissa J., Walsh, Kenneth, Grinnell, Alan D., Crosbie, Rachelle H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049356/
https://ncbi.nlm.nih.gov/pubmed/21245083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr015
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