An ATM/Chk2-mediated DNA damage responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells

Epstein-Barr virus (EBV), an oncogenic herpesvirus that causes human malignancies, infects and immortalizes primary human B cells in vitro into indefinitely proliferating lymphoblastoid cell lines, which represent a model for EBV-induced tumorigenesis. The immortalization efficiency is very low sugg...

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Autors principals: Nikitin, Pavel A., Yan, Christopher M., Forte, Eleonora, Bocedi, Alessio, Tourigny, Jason P., White, Robert E., Allday, Martin J., Patel, Amee, Dave, Sandeep S., Kim, William, Hu, Katherine, Guo, Jing, Tainter, David, Rusyn, Elena, Luftig, Micah A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049316/
https://ncbi.nlm.nih.gov/pubmed/21147465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.11.004
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