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Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
Spliceostatin A (SSA) is a stabilized derivative of a Pseudomonas bacterial fermentation product that displays potent anti-proliferative and anti-tumor activities in cancer cells and animal models. The drug inhibits pre-mRNA splicing in vitro and in vivo and binds SF3b, a protein subcomplex of U2 sm...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049286/ https://ncbi.nlm.nih.gov/pubmed/21363963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2014311 |
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