Effective mobilization of hematopoietic progenitor cells in G-CSF mobilization defective CD26(-/-) mice through AMD3100-induced disruption of the CXCL12-CXCR4 axis

OBJECTIVE: We previously reported that inhibition or loss of CD26 (DPPIV/dipeptidylpeptidase IV) results in a defect in normal mobilization of hematopoietic stem and progenitor cells induced by granulocyte-colony stimulating factor (G-CSF). This suggests that CD26 is a necessary component of the mob...

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Main Authors: Paganessi, Laura A., Walker, Andrew L., Tan, Lydia Luy, Holmes, Isaac, Rich, Elizabeth, Fung, Henry C., Christopherson, Kent W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049260/
https://ncbi.nlm.nih.gov/pubmed/21168468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2010.12.003
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