Small RNA-mediated regulation of iPS cell generation

Somatic cells can be reprogrammed to an ES-like state to create induced pluripotent stem cells (iPSCs) by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and cMyc. Here, we show that cellular microRNAs (miRNAs) regulate iPSC generation. Knock-down of key microRNA pathway proteins...

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Bibliographic Details
Main Authors: Li, Zhonghan, Yang, Chao-Shun, Nakashima, Katsuhiko, Rana, Tariq M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049216/
https://ncbi.nlm.nih.gov/pubmed/21285944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.2
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