Functional Integration of Grafted Neural Stem Cell-Derived Dopaminergic Neurons Monitored by Optogenetics in an In Vitro Parkinson Model

Intrastriatal grafts of stem cell-derived dopamine (DA) neurons induce behavioral recovery in animal models of Parkinson's disease (PD), but how they functionally integrate in host neural circuitries is poorly understood. Here, Wnt5a-overexpressing neural stem cells derived from embryonic ventr...

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Détails bibliographiques
Auteurs principaux: Tønnesen, Jan, Parish, Clare L., Sørensen, Andreas T., Andersson, Angelica, Lundberg, Cecilia, Deisseroth, Karl, Arenas, Ernest, Lindvall, Olle, Kokaia, Merab
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048875/
https://ncbi.nlm.nih.gov/pubmed/21394212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017560
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