Reconstitution of Proapoptotic BAK Function in Liposomes Reveals a Dual Role for Mitochondrial Lipids in the BAK-driven Membrane Permeabilization Process

BAK is a key effector of mitochondrial outer membrane permeabilization (MOMP) whose molecular mechanism of action remains to be fully dissected in intact cells, mainly due to the inherent complexity of the intracellular apoptotic machinery. Here we show that the core features of the BAK-driven MOMP...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Landeta, Olatz, Landajuela, Ane, Gil, David, Taneva, Stefka, DiPrimo, Carmelo, Sot, Begoña, Valle, Mikel, Frolov, Vadim A., Basañez, Gorka
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048708/
https://ncbi.nlm.nih.gov/pubmed/21196599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165852
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