Reconstitution of Proapoptotic BAK Function in Liposomes Reveals a Dual Role for Mitochondrial Lipids in the BAK-driven Membrane Permeabilization Process

BAK is a key effector of mitochondrial outer membrane permeabilization (MOMP) whose molecular mechanism of action remains to be fully dissected in intact cells, mainly due to the inherent complexity of the intracellular apoptotic machinery. Here we show that the core features of the BAK-driven MOMP...

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Detalhes bibliográficos
Main Authors: Landeta, Olatz, Landajuela, Ane, Gil, David, Taneva, Stefka, DiPrimo, Carmelo, Sot, Begoña, Valle, Mikel, Frolov, Vadim A., Basañez, Gorka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048708/
https://ncbi.nlm.nih.gov/pubmed/21196599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165852
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