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Oncogenic Activity of Ect2 Is Regulated through Protein Kinase Cι-mediated Phosphorylation
The Rho GTPase guanine nucleotide exchange factor Ect2 is genetically and biochemically linked to the PKCι oncogene in non-small cell lung cancer (NSCLC). Ect2 is overexpressed and mislocalized to the cytoplasm of NSCLC cells where it binds the oncogenic PKCι-Par6 complex, leading to activation of t...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048701/ https://ncbi.nlm.nih.gov/pubmed/21189248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196113 |
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