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C20-D(3)-vitamin A Slows Lipofuscin Accumulation and Electrophysiological Retinal Degeneration in a Mouse Model of Stargardt Disease

Stargardt disease, also known as juvenile macular degeneration, occurs in approximately one in 10,000 people and results from genetic defects in the ABCA4 gene. The disease is characterized by premature accumulation of lipofuscin in the retinal pigment epithelium (RPE) of the eye and by vision loss....

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Main Authors: Ma, Li, Kaufman, Yardana, Zhang, Junhua, Washington, Ilyas
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048683/
https://ncbi.nlm.nih.gov/pubmed/21156790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.178657
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