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Deuterium Enrichment of Vitamin A at the C20 Position Slows the Formation of Detrimental Vitamin A Dimers in Wild-type Rodents

Degenerative eye diseases are the most common causes of untreatable blindness. Accumulation of lipofuscin (granular deposits) in the retinal pigment epithelium (RPE) is a hallmark of major degenerative eye diseases such as Stargardt disease, Best disease, and age-related macular degeneration. The in...

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Detalles Bibliográficos
Main Authors: Kaufman, Yardana, Ma, Li, Washington, Ilyas
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048682/
https://ncbi.nlm.nih.gov/pubmed/21075840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.178640
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