NADPH Oxidase Activation in Pancreatic Cancer Cells Is Mediated through Akt-dependent Up-regulation of p22(phox)

We recently showed that Nox4 NADPH oxidase is highly expressed in pancreatic ductal adenocarcinoma and that it is activated by growth factors and plays a pro-survival, anti-apoptotic role. Here we investigate the mechanisms through which insulin-like growth factor I and serum (FBS) activate NADPH ox...

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Autors principals: Edderkaoui, Mouad, Nitsche, Claudia, Zheng, Ling, Pandol, Stephen J., Gukovsky, Ilya, Gukovskaya, Anna S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048665/
https://ncbi.nlm.nih.gov/pubmed/21118808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200063
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