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Omalizumab in the management of patients with allergic (IgE-mediated) asthma

Immunoglobulin E (IgE) is central to the pathophysiology of allergic asthma. Omalizumab, an anti-IgE monoclonal antibody, binds to the FcɛRI binding site on free IgE. As a result, circulating free IgE is reduced, IgE is prevented from attaching to mast cells and basophils, and FcɛRI receptor express...

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Hlavní autor: Sandström, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048609/
https://ncbi.nlm.nih.gov/pubmed/21437144
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