Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice

BACKGROUND: Toll-like receptor-4 (TLR4) triggers inflammatory signaling in response to microbial lipoploysaccharide. It has been reported that loss of TLR4 protected against saturated fat-induced inflammation and insulin resistance. It is not known whether loss of TLR4 function offers protection aga...

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Detalhes bibliográficos
Main Authors: Vijay-Kumar, Matam, Aitken, Jesse D, Carvalho, Frederic A, Ziegler, Thomas R, Gewirtz, Andrew T, Ganji, Vijay
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048481/
https://ncbi.nlm.nih.gov/pubmed/21314942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-8-2
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