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Structural determinants of ligand imprinting: A molecular dynamics simulation study of subtilisin in aqueous and apolar solvents
The phenomenon known as “ligand imprinting” or “ligand-induced enzyme memory” was first reported in 1988, when Russell and Klibanov observed that lyophilizing subtilisin in the presence of competitive inhibitors (that were subsequently removed) could significantly enhance its activity in an apolar s...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048422/ https://ncbi.nlm.nih.gov/pubmed/21280129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.569 |
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