FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration

Fused in Sarcoma (FUS) proteinopathy is a feature of frontotemporal lobar dementia (FTLD), and mutation of the fus gene segregates with FTLD and amyotrophic lateral sclerosis (ALS). To study the consequences of mutation in the fus gene, we created transgenic rats expressing the human fus gene with o...

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Detalhes bibliográficos
Main Authors: Huang, Cao, Zhou, Hongxia, Tong, Jianbin, Chen, Han, Liu, Yong-Jian, Wang, Dian, Wei, Xiaotao, Xia, Xu-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048370/
https://ncbi.nlm.nih.gov/pubmed/21408206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002011
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