FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration

Fused in Sarcoma (FUS) proteinopathy is a feature of frontotemporal lobar dementia (FTLD), and mutation of the fus gene segregates with FTLD and amyotrophic lateral sclerosis (ALS). To study the consequences of mutation in the fus gene, we created transgenic rats expressing the human fus gene with o...

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Autors principals: Huang, Cao, Zhou, Hongxia, Tong, Jianbin, Chen, Han, Liu, Yong-Jian, Wang, Dian, Wei, Xiaotao, Xia, Xu-Gang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048370/
https://ncbi.nlm.nih.gov/pubmed/21408206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002011
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