Estrogen Receptor α and Aromatase Polymorphisms Affect Risk, Prognosis, and Therapeutic Outcome in Men with Castration-Resistant Prostate Cancer Treated with Docetaxel-Based Therapy

CONTEXT: Reactive estrogen species cause genotoxicity and interfere with docetaxel-mediated tubulin polymerization resulting in shortened survival in men with castrate-resistant prostate cancer (CRPC). OBJECTIVE: We hypothesized that polymorphisms in estrogen synthesis and estrogen targets (i.e., CY...

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Détails bibliographiques
Auteurs principaux: Sissung, Tristan M., Danesi, Romano, Kirkland, C. Tyler, Baum, Caitlin E., Ockers, Sandra B., Stein, Erica V., Venzon, David, Price, Douglas K., Figg, William D.
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2011
Sujets:
JCEM Online: Brief Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048329/
https://ncbi.nlm.nih.gov/pubmed/21106711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-2070
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