One-year Treatment of Morpholino Antisense Oligomer Improves Skeletal and Cardiac Muscle Functions in Dystrophic mdx Mice

Antisense therapy has been successful to skip targeted dystrophin exon with correction of frameshift and nonsense mutations of Duchenne muscular dystrophy (DMD). Systemic production of truncated but functional dystrophin proteins has been achieved in animal models. Furthermore, phase I/II clinical t...

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Detalhes bibliográficos
Main Authors: Wu, Bo, Xiao, Bin, Cloer, Caryn, Shaban, Mona, Sali, Arpana, Lu, Peijuan, Li, Juan, Nagaraju, Kanneboyina, Xiao, Xiao, Lu, Qi Long
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048192/
https://ncbi.nlm.nih.gov/pubmed/21179007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.288
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