Development of B-lineage Predominant Lentiviral Vectors for Use in Genetic Therapies for B Cell Disorders

Sustained, targeted, high-level transgene expression in primary B lymphocytes may be useful for gene therapy in B cell disorders. We developed several candidate B-lineage predominant self-inactivating lentiviral vectors (LV) containing alternative enhancer/promoter elements including: the immunoglob...

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Detalhes bibliográficos
Main Authors: Sather, Blythe D, Ryu, Byoung Y, Stirling, Brigid V, Garibov, Mikhail, Kerns, Hannah M, Humblet-Baron, Stéphanie, Astrakhan, Alexander, Rawlings, David J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048182/
https://ncbi.nlm.nih.gov/pubmed/21139568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.259
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