Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.

Eitemau Tebyg

• Somatic diversification of the S107 (T15) VH11 germ-line gene that encodes the heavy-chain variable region of antibodies to double-stranded DNA in (NZB x NZW)F1 mice.
  gan: Behar, S M, et al.
  Cyhoeddwyd: (1988)
• Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.
  gan: Diamond, B, et al.
  Cyhoeddwyd: (1984)
• Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.
  gan: Giusti, A M, et al.
  Cyhoeddwyd: (1992)
• Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype.
  gan: Demaison, C, et al.
  Cyhoeddwyd: (1994)
• A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation.
  gan: Siminovitch, K A, et al.
  Cyhoeddwyd: (1989)