The same beta-globin gene mutation is present on nine different beta-thalassemia chromosomes in a Sardinian population.

The predominant beta-thalassemia in Sardinia is the beta 0 type in which no beta-globin chains are synthesized in the homozygous state. We determined the beta-thalassemia mutations in this population by the oligonucleotide-probe method and defined the chromosome haplotypes on which the mutation resi...

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Bibliographic Details
Main Authors: Pirastu, M, Galanello, R, Doherty, M A, Tuveri, T, Cao, A, Kan, Y W
Format: Artigo
Language:Inglês
Published: 1987
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC304764/
https://ncbi.nlm.nih.gov/pubmed/3033668
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