Diversification of a β-Lactam Pharmacophore via Allylic C—H Amination: Accelerating Effect of Lewis Acid Co-Catalyst

This report describes the use of Pd(II)/bis-sulfoxide 1 catalyzed intra- and intermolecular allylic C—H amination reactions to rapidly diversify structures containing a sensitive β-lactam core similar to that found in the monobactam antibiotic Aztreonam. Pharmacologically interesting oxazolidinone,...

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Main Authors: Qi, Xiangbing (Ben), Rice, Grant T., Lall, Manjinder S., Plummer, Mark S., White, M. Christina
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047472/
https://ncbi.nlm.nih.gov/pubmed/21379377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2010.04.064
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