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Diversification of a β-Lactam Pharmacophore via Allylic C—H Amination: Accelerating Effect of Lewis Acid Co-Catalyst
This report describes the use of Pd(II)/bis-sulfoxide 1 catalyzed intra- and intermolecular allylic C—H amination reactions to rapidly diversify structures containing a sensitive β-lactam core similar to that found in the monobactam antibiotic Aztreonam. Pharmacologically interesting oxazolidinone,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3047472/ https://ncbi.nlm.nih.gov/pubmed/21379377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2010.04.064 |
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