Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level

The covalent attachment of ubiquitin to proteins regulates numerous processes in eukaryotic cells. Here we report the identification of 753 unique lysine ubiquitylation sites on 471 proteins using higher-energy collisional dissociation on the LTQ Orbitrap Velos. In total 5756 putative ubiquitin subs...

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Hauptverfasser: Danielsen, Jannie M. R., Sylvestersen, Kathrine B., Bekker-Jensen, Simon, Szklarczyk, Damian, Poulsen, Jon W., Horn, Heiko, Jensen, Lars J., Mailand, Niels, Nielsen, Michael L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047152/
https://ncbi.nlm.nih.gov/pubmed/21139048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.003590
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