The induction of S100p expression by the Prostaglandin E(2) (PGE(2))/EP4 receptor signaling pathway in colon cancer cells

BACKGROUND: Prostaglandin E(2) (PGE(2)) levels are frequently elevated in colorectal carcinomas. PGE(2) is perceived via four transmembrane G protein coupled receptors (EP1-4), among which the EP4 receptor is most relevant. PGE(2)/EP4-receptor interaction activates CREB via the ERK/MEK pathway. Howe...

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Autors principals: Chandramouli, Anupama, Mercado-Pimentel, Melania E, Hutchinson, Anthony, Gibadulinová, Adriana, Olson, Erik R, Dickinson, Sally, Shañas, Reneé, Davenport, Jennifer, Owens, Janae, Bhattacharyya, Achyut K, Regan, John W, Pastorekova, Silvia, Arumugam, Thiruvengadam, Logsdon, Craig D, Nelson, Mark A
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2010
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047097/
https://ncbi.nlm.nih.gov/pubmed/20890108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.10.13373
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