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TNF neutralization results in disseminated disease during acute and latent M. tuberculosis infection with normal granuloma structure
An increased risk of tuberculosis has been documented in humans treated with tumor necrosis factor alpha (TNF) neutralizing agents. In murine models, impaired signaling by TNF caused exacerbation of both acute and chronic infection associated with aberrant granuloma formation and maintenance. The no...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3047004/ https://ncbi.nlm.nih.gov/pubmed/20112395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27271 |
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