Carbonylation Contributes to SERCA2a Activity Loss and Diastolic Dysfunction in a Rat Model of Type 1 Diabetes

OBJECTIVE: Approximately 25% of children and adolescents with type 1 diabetes will develop diastolic dysfunction. This defect, which is characterized by an increase in time to cardiac relaxation, results in part from a reduction in the activity of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERC...

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Detalhes bibliográficos
Main Authors: Shao, Chun Hong, Capek, Haley L., Patel, Kaushik P., Wang, Mu, Tang, Kang, DeSouza, Cyrus, Nagai, Ryoji, Mayhan, William, Periasamy, Muthu, Bidasee, Keshore R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046856/
https://ncbi.nlm.nih.gov/pubmed/21300842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1145
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