Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers

INTRODUCTION: The majority of breast cancers that occur in BRCA1 mutation carriers (BRCA1 carriers) are estrogen receptor-negative (ER-). Therefore, it has been suggested that ER negativity is intrinsic to BRCA1 cancers and reflects the cell of origin of these tumors. However, approximately 20% of b...

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Main Authors:	Tung, Nadine, Miron, Alexander, Schnitt, Stuart J, Gautam, Shiva, Fetten, Katharina, Kaplan, Jennifer, Yassin, Yosuf, Buraimoh, Ayodele, Kim, Ji-Young, Szász, Attila M, Tian, Ruiyang, Wang, Zhigang C, Collins, Laura C, Brock, Jane, Krag, Karen, Legare, Robert D, Sgroi, Dennis, Ryan, Paula D, Silver, Daniel P, Garber, Judy E, Richardson, Andrea L
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2010
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3046438/ https://ncbi.nlm.nih.gov/pubmed/21080930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2776
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Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers

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