Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia

BACKGROUND: Dysfunctioning of CCAAT/enhancer binding protein α (C/EBPα) in acute myeloid leukemia can be caused, amongst others, by mutations in the encoding gene (CEBPA) and by promoter hypermethylation. CEBPA-mutated acute myeloid leukemia is associated with a favorable outcome, but this may be re...

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主要な著者: Hollink, Iris H.I.M., van den Heuvel-Eibrink, Marry M., Arentsen-Peters, Susan T.C.J.M., Zimmermann, Martin, Peeters, Justine K., Valk, Peter J.M., Balgobind, Brian V., Sonneveld, Edwin, Kaspers, Gertjan J.L., de Bont, Eveline S.J.M., Trka, Jan, Baruchel, Andre, Creutzig, Ursula, Pieters, Rob, Reinhardt, Dirk, Zwaan, C. Michel
フォーマット: Artigo
言語:Inglês
出版事項: Ferrata Storti Foundation 2011
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Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046269/
https://ncbi.nlm.nih.gov/pubmed/21134981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.031336
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