Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia

BACKGROUND: Dysfunctioning of CCAAT/enhancer binding protein α (C/EBPα) in acute myeloid leukemia can be caused, amongst others, by mutations in the encoding gene (CEBPA) and by promoter hypermethylation. CEBPA-mutated acute myeloid leukemia is associated with a favorable outcome, but this may be re...

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Main Authors: Hollink, Iris H.I.M., van den Heuvel-Eibrink, Marry M., Arentsen-Peters, Susan T.C.J.M., Zimmermann, Martin, Peeters, Justine K., Valk, Peter J.M., Balgobind, Brian V., Sonneveld, Edwin, Kaspers, Gertjan J.L., de Bont, Eveline S.J.M., Trka, Jan, Baruchel, Andre, Creutzig, Ursula, Pieters, Rob, Reinhardt, Dirk, Zwaan, C. Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046269/
https://ncbi.nlm.nih.gov/pubmed/21134981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.031336
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