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Dynamics of mutant BCR-ABL-positive clones after cessation of tyrosine kinase inhibitor therapy
BACKGROUND: Point mutations of the BCR-ABL tyrosine kinase domain are considered the predominant cause of imatinib resistance in chronic myeloid leukemia. The expansion of mutant BCR-ABL-positive clones under selective pressure of tyrosine kinase inhibition is referred to as clonal selection; there...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Ferrata Storti Foundation
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3046266/ https://ncbi.nlm.nih.gov/pubmed/21134983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.030999 |
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