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Toxicity and tolerance mechanisms for azidothymidine, a replication gap-promoting agent, in Escherichia coli
Azidothymidine (AZT, zidovudine) is used to treat HIV-AIDS and prevent maternal transmission to newborns. Because the azido group replaces the 3′ OH of thymidine, AZT is believed to act as a chain terminator during reverse transcription of viral RNA into DNA, although other mechanisms of viral inhib...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3046245/ https://ncbi.nlm.nih.gov/pubmed/21145792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.11.007 |
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