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Toxicity and tolerance mechanisms for azidothymidine, a replication gap-promoting agent, in Escherichia coli

Azidothymidine (AZT, zidovudine) is used to treat HIV-AIDS and prevent maternal transmission to newborns. Because the azido group replaces the 3′ OH of thymidine, AZT is believed to act as a chain terminator during reverse transcription of viral RNA into DNA, although other mechanisms of viral inhib...

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Detalhes bibliográficos
Main Authors: Cooper, Deani L., Lovett, Susan T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046245/
https://ncbi.nlm.nih.gov/pubmed/21145792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.11.007
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