Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci

BACKGROUND: Common single-nucleotide polymorphisms (SNPs) in ten chromosomal loci have been shown to predispose to colorectal cancer (CRC) in genome-wide association studies. A plausible biological mechanism of CRC susceptibility associated with genetic variation has so far only been proposed for th...

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Main Authors: Niittymäki, Iina, Tuupanen, Sari, Li, Yilong, Järvinen, Heikki, Mecklin, Jukka-Pekka, Tomlinson, Ian PM, Houlston, Richard S, Karhu, Auli, Aaltonen, Lauri A
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045878/
https://ncbi.nlm.nih.gov/pubmed/21314996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-12-23
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