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p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior
Normal tissue cells survive and proliferate only while anchored to solid substrate. Conversely, transformed cells both survive and proliferate following detachment, having lost attachment context through unclear mechanisms. p66(Shc) is a focal adhesion-associated protein that reports cell attachment...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3045677/ https://ncbi.nlm.nih.gov/pubmed/20676142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.326 |
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