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Mono- and tri-cationic porphyrin–monoclonal antibody conjugates: photodynamic activity and mechanism of action

Two cationic porphyrins bearing an isothiocyanate group for conjugation to monocolonal antibodies have been synthesized. The two porphyrins conjugated efficiently to three monoclonal antibodies (anti-CD104, anti-CD146 and anti-CD326), which recognize antigens commonly over-expressed on a range of tu...

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Autors principals: Smith, Karen, Malatesti, Nela, Cauchon, Nicole, Hunting, Darel, Lecomte, Roger, van Lier, Johan E, Greenman, John, Boyle, Ross W
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045661/
https://ncbi.nlm.nih.gov/pubmed/21039468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2010.03359.x
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